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ALPHA KARYOPHERINS
Descriptors Found:
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DeCS
Descriptor
English
:
alpha Karyopherins
Descriptor
Spanish
:
alfa Carioferinas
Descriptor
Portuguese
:
alfa Carioferinas
Synonyms
English
:
Importin-alpha
Karyopherin alpha
NLS Receptor
NLS-Binding Protein
NLSBP
Nuclear Localization Sequence Receptor
Nuclear Localization Signal-Binding Protein
Karyopherins, alpha
receptor, NLS
Tree Number:
D12.776.157.530.750.500.100
D12.776.543.585.750.500.100
D12.776.660.502.100
Definition
English
:
Nucleocytoplasmic transport molecules that bind to the
NUCLEAR LOCALIZATION SIGNALS
of cytoplasmic molecules destined to be imported into the
CELL NUCLEUS
. Once attached to their cargo they bind to
BETA KARYOPHERINS
and are transported through the
NUCLEAR PORE
COMPLEX. Inside the
CELL NUCLEUS
alpha karyopherins
dissociate from beta karypherins and their cargo. They then form a complex with
CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN
and
RAN GTP-BINDING PROTEIN
which is exported to the
CYTOPLASM.
See Related
English
:
Nuclear Localization Signals
History Note
English
:
2002; use ALPHA KARYOPHERINS (NM) 1994-2001; for IMPORTIN-ALPHA use KARYOPHERINS 1995-2001; for NLS-BINDING PROTEIN, NLSBP & NUCLEAR LOCALIZATION SIGNAL-BINDING PROTEIN use NOPP140 (NM) 1992-2001
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
36192
Unique Identifier:
D028901
Occurrence in VHL
:
Similar:
DeCS
CID-10
LILACS